Description
Basic Pharmacokinetics provides an understanding of the principles of pharmacokinetics and biopharmaceutics. This book addresses clearly and concisely how these principles can be applied to achieve successful drug therapy. The applications of principles and equations are illustrated with related problem sets and problem solving exercises. Features include:
- the use of profiles (sketches of relationships among pharmacokinetic variables and parameters)
- learning objectives
- complete review of mathematical tools required to practice pharmacokinetics.
This edition has been revised and updated to include:
- new chapters on metabolite pharmacokinetics and pharmacokinetic data fitting
- expanded question data base to include multiple choice questions and true/false questions
- a large increase in the number of questions based on pharmacokinetic profiles.
Basic Pharmacokinetics is an invaluable textbook for students.
Introduction and Overview
• Mathematical Review
• Intravenous Bolus Administration (One-compartment Model)
• Clearance Concepts
Problem Set 1
- Drug Absorption From the Gastrointestinal Tract
- Extravascular Routes of Drug Administration
Problem Set 2
• Bioavilability/bioequivalence
Problem Set 3
• Factors Affecting Drug Absorption: Physicochemical Factors
• Gastrointestinal Absorption: Role of the Dosage Form
Continuous Intravenous Infusion (One-compartment Model)
Problem Set 4
• Multiple Dosing: Intravenous Bolus Administration
• Multiple Dosing: Extravascular Routes of Drug Administration
Problem Set 5
• Two-compartment Model
Problem Set 6
• Multiple Intermittent Infusions
Problem Set 7
• Nonlinear Pharmacokinetics
Problem Set 8
• Drug Interactions
Problem Set 9
• Pharmacokinetic and Pharmacodynamic Relationships
Problem Set 10
• Metabolite Pharmacokinetics
• Pharmacokinetic Data Fitting
• Pharmacokinetics and Pharmacodynamics of Biotechnology Drugs
Appendix: Statistical Moment Theory in Pharmacokinetics
